Endocrine Abstracts

Introduction: Over the past decades diabetes emerged as epidemic dimension due to person’s genetic pre disposition and environmental condition. Despite significant advancement in the development of oral hypoglycemic agents, an ideal drug for treating T2DM and its complication is still a distant reality. Hyperglycemia has a variety of toxic effects, including elevated generation of ROS nitrosative stress and inflammation. This work attempts to explore the role of oxidative...

Patient information is increasingly well provided, but little is known of patients' actual understanding of their conditions. The aim of this study was to determine the level of knowledge about thyrotoxicosis and its treatment among patients attending the endocrine clinic. Consecutive patients who had received antithyroid drugs were identified from the clinic database and asked to respond to a postal questionnaire. Ethical approval was obtained for the study.Questionnaires...

A 38-year-old farmer presented to Orthopaedics Department with backache and progressively increasing difficulty in walking for a year. MRI spine showed multiple central vertebral fractures suggestive of possible metabolic bone disease/oncogenic osteomalacia; he was hence referred to Endocrinology Department.He was in pain. No previous history of trauma, no gastrointestinal or urinary symptoms. He however reported erectile dysfunction. On...

Background: Polycystic ovarian syndrome (PCOS) is the commonest endocrine condition affecting women of reproductive age, often adversely impacting their quality of life. Delayed diagnosis and poor patient experience are common themes reported by affected women. Several factors contribute to poor clinical care including the lack of specialised multi-disciplinary clinics and poor clinician familiarity with the varied health needs of affected women. We aimed to i...

Background: Indeterminate thyroid nodules pose a diagnostic dilemma and the patients often undergo unnecessary surgeries or repeat surgery. Currently different molecular methods for detection of driver mutations are being used for better characterisation of these nodules. These methods are costly and not widely available all over the world. Currently use of liquid biopsy by measurement of cell-free DNA (cfDNA) levels from plasma has been useful in diagnosis and follow up of ca...

Introduction: Molecular testing is being increasingly used to detect malignancy in indeterminate thyroid nodules (Bethesda 3 & 4) which pose diagnostic dilemma. Long non-coding RNAs are crucial for metastasis, angiogenesis, and tumour growth of various cancers. Clinical utility of plasma lncRNAs as non-invasive diagnostic markers for thyroid cancer especially in indeterminate nodule remains unexplored.Methodology: We selected lncRNAs relevant to thyr...

Introduction: Cell-free DNA (cfDNA) integrity in plasma has been investigated as a non-invasive marker in cancer. Thyroid cancer the most common endocrine malignancy sometimes presents as indeterminate nodules and difficult to diagnose without histopathology.Aim of the study: The present study aims to test the hypothesis that the presence of longer DNA strands circulating in plasma can be considered a marker for thyroid cancer.Meth...

Background: Renal involvement in T2DM can be due to diabetes per se (Diabetic Kidney Disease) or causes other than diabetes (non-diabetic kidney disease). Currently available clinical, biochemical, and radiological markers fail to differentiate DKD from NDKD. Renal biopsy remains gold standard for diagnosis. Urinary signatures may provide a non-invasive alternative to that end. In cell culture and in animal models with diabetes and kidney disease, dysregulation of several meta...